Several Burkholderia species are highly pathogenic and intrinsically resistant to multiple classes of antibiotics. However, manipulating the structure of their outer membranes could increase their sensitivity to treatment.
In a recent study, Postdoctoral Fellow Dr. Steve Bernier, Dr. Michael Surette, and Surette lab graduate student Susie Son show that the Mla pathway – a system involved in maintaining cell wall integrity – is genetically and functionally different within several species of Burkholderia in comparison to other proteobacteria.
Their results suggest that this pathway could represent an ideal genus-specific target to address Burkholderia’s intrinsic resistance to antimicrobials.
Read the full publication in the Journal of Bacteriology.