Antimicrobial resistance arises through multiple mechanisms, one of which is the ability of bacteria to survive DNA damage. The Andres lab research interests are to understand the fundamental molecular mechanisms behind bacterial DNA damage response and repair pathways that contribute to microbial survival. We utilize a combination of structural biology, biochemistry, and cell biology to determine the unique and critical protein and nucleic acid components in these pathways that can be targeted for new therapeutic strategies aimed at drug resistant infections.
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