News Reports & Publications

Screening Platform Targets Bacterial Processes Necessary for E. coli Growth under Nutrient Stress 

Authors Sara El Zahed (left), Garima Kumar (center), and Madeline Tong (right).

Seeking to expand the currently limited target base of antibacterial drug discovery, Brown lab trainees Sara El Zahed, Garima Kumar, and Madeline Tong applied a nutrient stress screening platform to Escherichia coli in an effort to identify inhibitors of E. coli growth under nutrient limitation. Under nutrient stress, the team was able to target processes that are necessary for certain pathogens to thrive at particular sites of infection. In full, the team’s screening platform helps shed light on potentially new targets for novel antibiotics.

 

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