News Reports & Publications

Wright lab discovers Rox gene’s unprecedented mechanism of rifamycin resistance in Cell Chemical Biology

Lead author of the publication, Dr. Kalinka Koteva, Research Associate of Dr. Gerry Wright’s lab.

Rox genes – or, rifamycin monooxygenases – are found in a variety of environmental bacteria, and are associated with the decomposition of the clinically important antibiotic rifampin. In a recent study in Cell Chemical Biology led by Dr. Kalinka Koteva and Dr. Georgina Cox of the Wright lab, the team takes a closer look at the structure and mechanism of resistance of Rox isolated from Streptomyces venezualae, uncovering a novel method of antibiotic detoxification. 

Read the full publication in Cell Chemical Biology.

Visit the Wright lab webpage here.