Yingfu Li, PhD
Professor, Department of Biochemistry and Biomedical Sciences
905-525-9140 ext. 22462
McMaster University, HSC 4H31B
1200 Main Street West
Hamilton, ON
L8N 3Z5
Li's laboratory is interested in developing point of care (POC) diagnostics to detect bacterial pathogens, particularly epidemic Clostridium difficle strains that are resistant to clindamycin, fluoroquinolones and metronidazole. These strains are recognized as the major cause of healthcare antibiotic-associated diarrhea. Their POC technology is based on molecular recognition elements that are made of synthetic DNA molecules (e.g. DNA aptamers and DNAzymes) and selected from synthetic random-sequence DNA pools using test-tube evolution experiments. These molecules are subsequently used to develop tests as simple as the classic litmus test for clinical use.