Russell Bishop, PhD
Associate Professor, Department of Biochemistry and Biomedical Sciences
905-525-9140 ext. 28810
McMaster University, HSC 4H19
1200 Main Street West
Hamilton, ON
L8N 3Z5
PagP is an outer membrane enzyme of Gram-negative bacteria that functions to modulate the host immune response to infections. PagP not only fortifies the outer membrane permeability barrier to provide enhanced antimicrobial resistance, but it can also function as a phospholipid-recycling sensory transducer. The co-evolution of eukaryotic hosts with bacteria has revealed multiple roles for PagP to guide the development of vaccine adjuvants and novel strategies to treat infections.