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Silent but deadly: IS200 Promotes Pathogenicity in Salmonella Typhimurium.

Research students in Dr. Eric Brown’s lab. From left to right: Craig MacNair (PhD candidate), Lindsey Carfrae (PhD candidate), and Michael Ellis (Post-doctoral fellow)

Bacterial insertion sequences were long presumed to be “junk” DNA. In a recent publication, this notion has been challenged with evidence that a dormant transposon encodes an overlooked regulatory RNA that is important for colonization of the mouse gastrointestinal tract by Salmonella Typhimurium. This study was led by Dr. Michael Ellis, a post-doc in the Dr. Eric Brown’s lab who began this project during his doctoral work in the Haniford Lab, in collaboration with Brown lab PhD candidates Lindsey Carfrae and Craig MacNair.

Read the full article in RNA Biology.