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Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.

 

Metallo-β-lactamases (MBLs) are notable enzymes that give rise to bacterial resistance against a broad range of beta-lactam antibiotics. Recently, within the CMCB, Dr. Gerry Wright’s research group discovered an inhibitor of MBLs called aspergillomarasmine A (AMA) – a compound currently in its late-stage preclinical development after being licensed to a Boston area pharmaceutical company. Within this recent publication, the interaction of aspergillomarasmine with various MBLs is explored, to reveal the mode of action of MBL inhibition.

Read the full publication here.