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Monocyte Activation is Elevated in Women with Knee-Osteoarthritis and Associated with Inflammation, BMI and Pain

Dessi Loukov, PhD candidate in Dr. Dawn Bowdish’s lab and lead author of the publication.

In a recent publication, Dr. Dawn Bowdish and her PhD student Dessi Loukov found that monocytes were more activated and pro-inflammatory in women with osteoarthritis, and that elevated inflammation and body mass index were associated with increased monocyte activation. Further, the team found that women with osteoarthritis and more activated monocytes experienced worse pain than individuals with less activated monocytes. These findings highlight the importance of modulating inflammation and body mass to manage osteoarthritis and open up new avenues for therapeutic research.

Read the full publication in the Osteoarthritis Research Society International (OARSI) Journal